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1

Socioeconomic burden of hereditary angioedema: results from the hereditary angioedema burden of illness study in Europe

Aygören-Pürsün, Emel, Bygum, Anette, Beusterien, Kathleen, Hautamaki, Emily, Sisic, Zlatko, Wait, Suzanne, Boysen, Henrik B, Caballero, Teresa

Journal:

Orphanet Journal of Rare Diseases

Year:

2014

Language:

english

File:

PDF, 553 KB

english, 2014

2

Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies

Aygören-Pürsün, Emel, Magerl, Markus, Maetzel, Andreas, Maurer, Marcus

Journal:

Orphanet Journal of Rare Diseases

Year:

2018

Language:

english

File:

PDF, 393 KB

english, 2018

3

Oral Prophylaxis with Berotralstat (BCX7353) Reduces Use of Standard of Care (SOC) On-demand Medication in Patients with Hereditary Angioedema (HAE): APeX-2 Study Results

Bernstein, Jonathan, Zuraw, Bruce, Aygoren-Pursun, Emel, Li, Huamin, Busse, Paula, Johnston, Douglas, Maurer, Marcus, Lumry, William, Riedl, Marc, Jacobs, Joshua, Sitz, Karl, Gagnon, Remi, Clemons, De

Journal:

Journal of Allergy and Clinical Immunology

Year:

2020

Language:

english

File:

PDF, 106 KB

english, 2020

4

HAE international home therapy consensus document

Hilary J Longhurst, Henriette Farkas, Timothy Craig, Emel Aygören-Pürsün, Claire Bethune, Janne Bjorkander, Konrad Bork, Laurence Bouillet, Henrik Boysen, Anette Bygum, Teresa Caballero, Marco Cicardi

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 249 KB

english, 2010

5

On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience

Emel Aygören-Pürsün, Inmaculada Martinez-Saguer, Eva Rusicke, Thomas Klingebiel, Wolfhart Kreuz

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 223 KB

english, 2010

6

C1-inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis

Wolfhart Kreuz, Inmaculada Martinez-Saguer, Emel Aygören-Pürsün, Eva Rusicke, Christine Heller, Thomas Klingebiel

Journal:

Transfusion (Wiley)

Year:

2009

Language:

english

File:

PDF, 232 KB

english, 2009

7

Home therapy with intravenous human C1-inhibitor in children and adolescents with hereditary angioedema

Wolfhart Kreuz, Eva Rusicke, Inmaculada Martinez-Saguer, Emel Aygören-Pürsün, Christine Heller, Thomas Klingebiel

Journal:

Transfusion (Wiley)

Year:

2012

Language:

english

File:

PDF, 109 KB

english, 2012

8

Pharmacokinetic analysis of human plasma–derived pasteurized C1-inhibitor concentrate in adults and children with hereditary angioedema: a prospective study

Inmaculada Martinez-Saguer, Eva Rusicke, Emel Aygören-Pürsün, Nils Von Hentig, Thomas Klingebiel, Wolfhart Kreuz

Journal:

Transfusion (Wiley)

Year:

2010

Language:

english

File:

PDF, 147 KB

english, 2010

9

Characterization of acute hereditary angioedema attacks during pregnancy and breast-feeding and their treatment with C1 inhibitor concentrate

Inmaculada Martinez-Saguer, Eva Rusicke, Emel Aygören-Pürsün, Christine Heller, Thomas Klingebiel, Wolfhart Kreuz

Journal:

American Journal of Obstetrics and Gynecology

Year:

2010

Language:

english

File:

PDF, 666 KB

english, 2010

10

Functional C1-Inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

Ineke G.A. Wagenaar-Bos, Christian Drouet, Emel Aygören-Pursun, Konrad Bork, Christoph Bucher, Anette Bygum, Henriette Farkas, George Fust, Hanna Gregorek, C. Erik Hack, Alaco Hickey, Helen I. Joller-

Journal:

Journal of Immunological Methods

Year:

2008

Language:

english

File:

PDF, 531 KB

english, 2008

11

Does long-term treatment alter the pharmacokinetics of human C1-esterase-inhibitor (C1-INH) in HAE patients?

Inmaculada Martinez-Saguer, Eva Rusicke, Emel Aygören-Pürsün, Thomas Klingebiel, Wolfhart Kreuz

Journal:

Molecular Immunology

Year:

2008

Language:

english

File:

PDF, 87 KB

english, 2008

12

Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema

Bowen, Tom, Cicardi, Marco, Farkas, Henriette, Bork, Konrad, Kreuz, Wolfhart, Zingale, Lorenza, Varga, Lilian, Martinez-Saguer, Inmaculada, Aygören-Pürsün, Emel, Binkley, Karen

Journal:

Journal of Allergy and Clinical Immunology

Year:

2004

Language:

english

File:

PDF, 562 KB

english, 2004

13

The hereditary angioedema burden of illness study in Europe (HAE-BOIS-Europe): background and methodology

Anette Bygum, Emel Aygören-Pürsün, Teresa Caballero, Kathleen Beusterien, Shadi Gholizadeh, Patience Musingarimi, Suzanne Wait, Henrik Boysen

Journal:

BMC Dermatology

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

14

Does Early Clinical Manifestation of Hereditary Angioedema (HAE) Influence the Clinical Course of the Disease?

Martinez-Saguer, Inmaculada, Graff, Jochen, Rusicke, Eva, Aygören-Pürsün, Emel, Klingebiel, Thomas, Kreuz, Wolfhart

Journal:

Journal of Allergy and Clinical Immunology

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

15

Pharmacokinetics of plasma-derived C1-esterase inhibitor after subcutaneous versus intravenous administration in subjects with mild or moderate hereditary angioedema: the PASSION study

Martinez-Saguer, Inmaculada, Cicardi, Marco, Suffritti, Chiara, Rusicke, Eva, Aygören-Pürsün, Emel, Stoll, Hildegard, Rossmanith, Tanja, Feussner, Annette, Kalina, Uwe, Kreuz, Wolfhart

Journal:

Transfusion (Elsevier)

Year:

2014

Language:

english

File:

PDF, 697 KB

english, 2014

16

Canadian hereditary angioedema guideline

Betschel, Stephen, Badiou, Jacquie, Binkley, Karen, Hébert, Jacques, Kanani, Amin, Keith, Paul, Lacuesta, Gina, Yang, Bill, Aygören-Pürsün, Emel, Bernstein, Jonathan, Bork, Konrad, Caballero, Teresa,

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 472 KB

english, 2014

17

The humanistic burden of hereditary angioedema: Results from the Burden of Illness Study in Europe

Caballero, Teresa, Aygören-Pürsün, Emel, Bygum, Anette, Beusterien, Kathleen, Hautamaki, Emily, Sisic, Zlatko, Wait, Suzanne, Boysen, Henrik B.

Journal:

Allergy and Asthma Proceedings

Year:

2014

Language:

english

File:

PDF, 168 KB

english, 2014

18

Prophylaxis of HAE Attacks: A Randomized Trial of Oral Plasma Kallikrein Inhibition with Avoralstat

Aygören-Pürsün, Emel, Magerl, Markus, Graff, Jochen, Martinez-Saguer, Inmaculada, Kreuz, Wolfhart, Longhurst, Hilary, Nasr, Iman, Bas, Murat, Straßen, Ulrich, Fang, Lei, Cornpropst, Melanie, Dobo, Syl

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

19

C1 Inhibitor for Routine Prophylaxis in Patients with Hereditary Angioedema: Interim Results from a European Registry Study

Aygören-Pürsün, Emel, Magerl, Markus, Martinez-Saguer, Inmaculada, Longhurst, Hilary J., Straßen, Ulrich, Martin, Ludovic, Caballero, Teresa, Staubach, Petra, Maurer, Marcus, Hamdani, Mohamed, Andrese

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 130 KB

english, 2016

20

BCX4161, an Oral Kallikrein Inhibitor, Showed Significant Benefits on Reducing Disease Burden and Improving Quality of Life in Subjects with Hereditary Angioedema in the Opus-1 Study

Magerl, Markus, Aygören-Pürsün, Emel, Graff, Jochen, Martinez-Saguer, Inmaculada, Kreuz, Wolfhart, Longhurst, Hilary, Nasr, Iman, Bas, Murat, Straßen, Ulrich, Weller, Karsten, Fang, Lei, Cornpropst, M

Journal:

Journal of Allergy and Clinical Immunology

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

21

Efficacy Correlates with Plasma Levels in Opus-1, a Proof-of-Concept Study of Oral Kallikrein Inhibitor BCX4161 As a Prophylaxis Against Attacks of Hereditary Angioedema (HAE)

Aygören-Pürsün, Emel, Magerl, Markus, Graff, Jochen, Martinez-Saguer, Inmaculada, Kreuz, Wolfhart, Longhurst, Hilary, Nasr, Iman, Bas, Murat, Straßen, Ulrich, Zong, Jian, Fang, Lei, Cornpropst, Melani

Journal:

Journal of Allergy and Clinical Immunology

Year:

2015

Language:

english

File:

PDF, 44 KB

english, 2015

22

Hereditary Angioedema Caused By C1-Esterase Inhibitor Deficiency: A Literature-Based Analysis and Clinical Commentary on Prophylaxis Treatment Strategies

Gower, Richard G., Busse, Paula J., Aygören-Pürsün, Emel, Barakat, Amin J., Caballero, Teresa, Davis-Lorton, Mark, Farkas, Henriette, Hurewitz, David S., Jacobs, Joshua S., Johnston, Douglas T., Lumry

Journal:

World Allergy Organization Journal

Year:

2011

Language:

english

File:

PDF, 968 KB

english, 2011

23

549 Management of Twenty-Five Pediatric Patients with Hereditary Angioedema (Hae) Undergoing Home Treatment—A Clinical Surveillance Program

Martinez-Saguer, Inmaculada, Aygören-Pürsün, Emel, Rusicke, Eva, Klingebiel, Thomas, Kreuz, Wolfhart

Journal:

World Allergy Organization Journal

Year:

2012

Language:

english

File:

PDF, 83 KB

english, 2012

24

Hereditary Angioedema Caused By C1-Esterase Inhibitor Deficiency: A Literature-Based Analysis and Clinical Commentary on Prophylaxis Treatment Strategies

Richard G Gower,Paula J Busse,Emel Aygören-Pürsün…

Journal:

World Allergy Organization Journal

Year:

2011

Language:

english

File:

PDF, 931 KB

english, 2011

25

Preventing Hereditary Angioedema Attacks in Children Using Cinryze®: Interim Efficacy and Safety Phase 3 Findings

Aygören-Pürsün, Emel, Soteres, Daniel, Moldovan, Dumitru, Christensen, Jim, Van Leerberghe, Arthur, Hao, James, Schranz, Jennifer, Jacobson, Kraig W., Martinez-Saguer, Inmaculada

Journal:

International Archives of Allergy and Immunology

Year:

2017

Language:

english

File:

PDF, 147 KB

english, 2017

26

Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: the OPUS-2 study

Riedl, Marc A., Aygören-Pürsün, Emel, Baker, James, Farkas, Henriette, Anderson, John, Bernstein, Jonathan A, Bouillet, Laurence, Busse, Paula, Manning, Michael, Magerl, Markus, Gompels, Mark, Huissoo

Journal:

Year:

2018

Language:

english

File:

PDF, 466 KB

english, 2018

27

The international WAO/EAACI guideline for the management of hereditary angioedema – the 2017 revision and update

Maurer, Marcus, Magerl, Markus, Ansotegui, Ignacio, Aygören-Pürsün, Emel, Betschel, Stephen, Bork, Konrad, Bowen, Tom, Boysen, Henrik Balle, Farkas, Henriette, Grumach, Anete S., Hide, Michihiro, Kate

Journal:

World Allergy Organization Journal

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

28

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema

Aygören-Pürsün, Emel, Bygum, Anette, Grivcheva-Panovska, Vesna, Magerl, Markus, Graff, Jochen, Steiner, Urs C., Fain, Olivier, Huissoon, Aarnoud, Kinaciyan, Tamar, Farkas, Henriette, Lleonart, Ramon,

Journal:

New England Journal of Medicine

Year:

2018

Language:

english

File:

PDF, 326 KB

english, 2018

29

Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema

Aygören-Pürsün, Emel, Bygum, Anette, Beusterien, Kathleen, Hautamaki, Emily, Sisic, Zlatko, Boysen, Henrik B, Caballero, Teresa

Journal:

Patient Preference and Adherence

Year:

2016

Language:

english

File:

PDF, 657 KB

english, 2016

30

Cinryze is Efficacious for Hereditary Angioedema (HAE) Attack Prevention In Pediatric Patients: Final Phase 3 Efficacy And Safety Results

Aygören-Pürsün, Emel, Soteres, Daniel F., Nieto–Martinez, Sandra, Christensen, Jim, Jacobson, Kraig W., Moldovan, Dumitru, Van Leerberghe, Arthur, Tang, Tom, Lu, Peng, Martinez-Saguer, Inmaculada

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 132 KB

english, 2018

31

Oral Plasma Kallikrein Inhibitor BCX7353 is Safe and Effective as an On-Demand Treatment of Angioedema Attacks in Hereditary Angioedema (HAE) Patients: Results of the ZENITH-1 Trial

Longhurst, Hilary, Moldovan, Dumitru, Bygum, Anette, Cicardi, Marco, Huissoon, Aarnoud, Aygoren-Pursun, Emel, Grivcheva-Panovska, Vesna, Hagin, David, Steiner, Urs, Stobiecki, Marcin, Aberer, Werner,

Journal:

Journal of Allergy and Clinical Immunology

Year:

2019

Language:

english

File:

PDF, 87 KB

english, 2019

32

Hereditäres Angioödem; Hereditary angioedema;

Aygören-Pürsün, Emel, Bork, Konrad

Journal:

Year:

2019

Language:

german

File:

PDF, 827 KB

german, 2019

33

Hereditäres Angioödem; Hereditary angioedema;

Aygören-Pürsün, Emel, Bork, Konrad

Journal:

Year:

2019

File:

PDF, 827 KB

2019

34

Hereditäres Angioödem; Hereditary angioedema;

Aygören-Pürsün, Emel, Bork, Konrad

Journal:

Year:

2019

File:

PDF, 638 KB

2019

35

The International/Canadian Hereditary Angioedema Guideline

Betschel, Stephen, Badiou, Jacquie, Binkley, Karen, Borici-Mazi, Rozita, Hébert, Jacques, Kanani, Amin, Keith, Paul, Lacuesta, Gina, Waserman, Susan, Yang, Bill, Aygören-Pürsün, Emel, Bernstein, Jonat

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2019

File:

PDF, 4.34 MB

2019

36

Hereditäres Angioödem; Hereditary angioedema;

Aygören-Pürsün, Emel, Bork, Konrad

Journal:

Pädiatrie & Pädologie

Year:

2019

File:

PDF, 638 KB

2019

37

Patterns of Treatment and Retreatment of Acute Attacks of Hereditary Angioedema (HAE) with Standard of Care (SOC) On-Demand Medication: Results from the APeX-2 Study

Aygoren-Pursun, Emel, Johnston, Douglas, Lumry, William, Li, Huamin, Banerji, Aleena, Zuraw, Bruce, Christiansen, Sandra, Kinaciyan, Tamar, Hanzlikova, Jana, Gower, Richard, Gagnon, Remi, Cicardi, Mar

Journal:

Journal of Allergy and Clinical Immunology

Year:

2020

File:

PDF, 105 KB

2020

38

Efficacy of Lanadelumab in Hereditary Angioedema Patients With and Without Prior Long-Term Prophylaxis Use: Interim Results From the HELP Open-Label Extension Study

Paes, Kim, Craig, Timothy, Bernstein, Jonathan, Longhurst, Hilary, Aygoren-Pursun, Emel, Nurse, Christina, Zuraw, Bruce, Jacobs, Joshua

Journal:

Journal of Allergy and Clinical Immunology

Year:

2020

File:

PDF, 107 KB

2020

39

Relative Reductions in Attack Rate With Prophylactic Berotralstat (BCX7353) in Subjects with Hereditary Angioedema (HAE): Responder Analysis from the APeX-2 Study

Lumry, William, Maurer, Marcus, Zuraw, Bruce, Banerji, Aleena, Riedl, Marc, Johnston, Douglas, Aygoren-Pursun, Emel, Jacobs, Joshua, Gower, Richard, Wedner, H. James, Sitz, Karl, Magerl, Markus, Cornp

Journal:

Journal of Allergy and Clinical Immunology

Year:

2020

File:

PDF, 106 KB

2020